Feng He

Feng He, Principal Investigator

Since Mar. 2015, Dr. Feng He has led the junior group of immune systems biology (GISB) from the Department of Infection and Immunity (DII) at LIH. He pursued his PhD (cumulative thesis) in experimental systems biology from Technical University of Braunschweig, Germany and Helmholtz Centre for Infection Research (HZI) with Prof. An-Ping Zeng and continued a 2-year postdoc training in Prof Klaus Schughart's lab. Afterwards, during his postdoctoral training ( 2010-2015) at Luxembourg Centre for Systems Biology in Prof. Rudi Balling’s lab and as a visiting researcher in University of Cambridge and Institute for Systems Biology, Seattle, Feng has developed various systems biology approaches to computationally predict and experimentally validate novel key gene candidates and gene networks from dynamic/time-series ‘omics’ datasets. Feng was originally trained in chemistry and biochemical engineering (MSc. degree, Department of Biochemical Engineering, Tianjin University, China, 2004). His network-guided experimental approaches have led to the discoveries of several novel key genes in immune cell functions. Dr. Feng He currently serves on the editorial board of several systems biology and medicine related journals, such as  Immunoinformatics from Elsevier and Network and Systems Medicine from Mary Ann Liebert.





House of BioHealth, DII/LIH
29, rue Henri Koch
L-4354 Esch-sur-Alzette


+352 26970 343




Key words:
T cells
Systems Immunology
Systems Biomedicine
Personalized Immunology
Time-series Analysis
Network Biology



Representative Publications:

Christophe M. Capelle, Ni Zeng, Egle Danileviciute, Sabrina Freitas Rodrigues, Markus Ollert, Rudi Balling, Feng Q. He#Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells, Cell Press iScience, 2021 Apr. 23, 24 (4): 4102289
To access: https://www.cell.com/iscience/fulltext/S2589-0042(21)00257-1

Massimiliano Zanin, Bruno F R Santos, Paul M A Antony, Clara Berenguer-Escuder, Simone B Larsen, Zoé Hanss, Peter A Barbuti, Aidos S Baumuratov, Dajana Grossmann, Christophe M Capelle, Joseph Weber, Rudi Balling, Markus Ollert, Rejko Krüger, Nico J Diederich, Feng Q. He#Mitochondria interaction networks show altered topological patterns in Parkinson's diseaseNpj Systems Biology and Applications, 2020 Nov 10, 6(1):38.
To access: https://www.nature.com/articles/s41540-020-00156-4

Sylvie Delhalle, Sebastian Bode, Rudi Balling, Markus Ollert, Feng Q. He#A Roadmap towards Personalized Immunology. Npj Systems Biology and Applications, 2018, Feb 6, 4:9. To access: https://www.nature.com/articles/s41540-017-0045-9

Feng He, Hairong Chen, Michael Probst-Kepper, Robert Geffers, Serge Eifes, Antonio del Sol, Klaus Schughart, An-Ping Zeng & Rudi Balling. PLAU inferred from a correlation network is critical for suppressor function of regulatory T cellsMolecular Systems Biology, 2012, 8:624-643. chosen as Featured Article in the journal
To access: https://www.embopress.org/doi/full/10.1038/msb.2012.56


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