Critical Transitions in Immunology

This project will experimentally study whether and how critical transitions occur in the immune system and whether early warning molecular subnetworks can be used for potential therapeutic interventions. The GISB is interested in exploring gene expression dynamics and the underlying regulatory networks (He 2009; He 2014), currently focusing on T-cells by measuring and analyzing genome-scale time-series data (Capelle, 2021; He, 2012; He and Balling, 2013). The experimental data will be further analyzed by the theoretical partners of the FNR-funded PRIDE project CRITICS DTU. The project will study a well-known phenotype that the human immune system might be impaired after a long-term exposure to chronic stresses, while being beneficial under acute stresses.